C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/00 (2006.01)
Patent
CA 2730776
The invention relates to neutralizing antibodies, and antibody fragments thereof, having high potency in neutralizing hCMV, wherein said antibodies and antibody fragments are specific for one, or a combination of two or more, hCMV gene UL products. The invention also relates to immortalized B cells that produce, and to epitopes that bind to, such antibodies and antibody fragments. In addition, the invention relates to the use of the antibodies, antibody fragments, and epitopes in screening methods as well as in the diagnosis, prevention, and therapy of disease.
La présente invention concerne des anticorps neutralisants, et des fragments danticorps de ceux-ci, ayant un pouvoir élevé de neutralisation de hCMV, où lesdits anticorps et fragments danticorps sont spécifiques dun, ou dune combinaison de deux ou plus, produit(s) de gène UL de hCMV. Linvention concerne en outre des lymphocytes B immortalisés qui produisent, et des épitopes qui se lient à, de tels anticorps et fragments danticorps. De plus, linvention concerne lutilisation des anticorps, fragments danticorps et épitopes dans des procédés de criblage ainsi que dans le diagnostic, la prévention et la thérapie de maladies.
Lanzavecchia Antonio
Macagno Annalisa
Institute For Research In Biomedicine
Osler Hoskin & Harcourt Llp
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