C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
530/7.1, 195/1.2
C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 14/52 (2006.01) C12P 21/02 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2006964
ABSTRACT OF THE DISCLOSURE: Pure peptide products, derived from either human glioma cell line U-105MG or human peripheral blood mononuclear leukocytes are provided; the products have a molecular mass of about 8,400 daltons, and the products exhibit optimal monocyte chemotactic activity at a concentration of 1 nM. The cloning of full length cDNA for the peptide products is also provided, as well as recombinant methods for the production of monocyte chemoattractant products. Methods of treating infection and neoplasms in a human body with such peptides and monocyte chemoattractant products are additionally provided, as well as pharmaceutical compositions for the same.
Appella Ettore
Leonard Edward J.
Robinson Elizabeth A.
Yoshimura Teizo
Appella Ettore
Gowling Lafleur Henderson Llp
Leonard Edward J.
Robinson Elizabeth A.
U.s. Department Of Commerce United States Of America Represented By The Secretary
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