C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/55 (2006.01) A61K 38/46 (2006.01) A61P 11/00 (2006.01) A61P 37/00 (2006.01) C12N 9/16 (2006.01)
Patent
CA 2257133
The present invention relates to amino acid sequence variants of human DNase I that have increased DNA-hydrolytic activity. The invention provides nucleic acid sequences encoding such hyperactive variants, thereby enabling the production of these variants in quantities sufficient for clinical use. The invention also relates to pharmaceutical compositions and therapeutic uses of hyperactive variants of human DNase I.
La présente invention concerne des variantes de séquences d'acides aminés de la désoxyribonucléase I humaine présentant une activité hydrolytique accrue de l'ADN. L'invention concerne également des séquences d'acides nucléiques codant pour de telles variantes hyperactives, ce qui permet la production de ces variantes en des quantités suffisantes pour une utilisation clinique. L'invention concerne enfin des compositions et des utilisations thérapeutiques de variantes hyperactives de la désoxyribonucléase I humaine.
Lazarus Robert A.
Pan Clark Qun
Dennison Associates
Genentech Inc.
LandOfFree
Human dnase i hyperactive variants does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Human dnase i hyperactive variants, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human dnase i hyperactive variants will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1658596