C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/22 (2006.01) A61K 38/46 (2006.01) A61P 11/12 (2006.01) C12N 9/16 (2006.01) C12N 15/55 (2006.01)
Patent
CA 2210871
The present invention relates to amino acid sequence variants of human DNase I that have reduced binding affinity for actin. The invention provides nucleic acid sequences encoding such actin-resistant variants, thereby enabling the production of these variants in quantities sufficient for clinical use. The invention also relates to pharmaceutical compositions and therapeutic uses of actin-resistant variants of human DNase I.
La présente invention concerne des variantes au niveau de la séquence des acides aminés de la DNAse I humaine ayant une affinité diminuée pour l'actine. L'invention concerne aussi des séquences d'acides nucléiques codant pour ces variantes résistantes à l'actine, et permet de produire ces variantes en quantité suffisante, pour une utilisation clinique. L'invention concerne également des compositions pharmaceutiques et l'utilisation thérapeutique des variantes de la DNAse I humaine résistantes à l'actine.
Lazarus Robert A.
Shak Steven
Ulmer Jana S.
Dennison Associates
Genentech Inc.
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