C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07H 21/00 (2006.01) C07K 14/00 (2006.01) C07K 14/705 (2006.01) C12P 21/06 (2006.01)
Patent
CA 2378610
The invention provides isolated nucleic acid and amino acid sequences of Eag2, antibodies to Eag2, methods of detecting Eag2, and methods of screening for modulators of Eag2 potassium channels using biologically active Eag2. The invention further provides, in a computer system, a method of screening for mutations of human Eag2 genes as well as a method for identifying a three- dimensional structure of Eag2 polypeptide monomers.
L'invention se rapporte à des séquences d'acides aminés et d'acides nucléiques isolés de Eag2, à des anticorps dirigés contre Eag2, à des méthodes de détection de Eag2 et à des procédés de sélection de modulateurs des canaux potassium de Eag2 au moyen d'Eag2 biologiquement actif. L'invention se rapporte en outre à un procédé mis en oeuvre sur un système informatique, qui permet le criblage de mutations de gènes humains Eag2 ainsi qu'à un procédé d'identification d'une structure tridimensionnelle de monomères polypeptides Eag2.
Jegla Timothy James
Liu Yi
Fetherstonhaugh & Co.
Icagen Inc.
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