Human elongase genes and uses thereof

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/54 (2006.01) C12N 9/10 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2429469

The present invention relates to elongase genes, their polypeptides and their control regions, and the use of such genes, polypeptides and control regions in determining compositions for use in the treatment of disease. The identified compositions regulate the expression of the elongase genes or modulate the activity of their protein products. The nucleotide and amino acid sequences are taught for ELG4, ELG6 and ELG7. The control sequences and function are taught for ELG1, ELG2, ELG3, ELG4, ELG5, ELG6 and ELG7.

La présente invention concerne des gènes de l'élongase, leurs polypeptides et leurs régions de contrôle, ainsi que l'utilisation de ces gènes, polypeptides et régions de contrôle pour identifier des compositions destinées à être utilisées dans le traitement de pathologies. Les compositions identifiées permettent de réguler l'expression des gènes de l'élongase ou de moduler l'activité de leurs produits protéinés. Les séquences nucléotidiques et d'acides aminés sont ELG4, ELG6 et ELG7. Les séquences et fonction de contrôle sont ELG1, ELG2, ELG3, ELG4, ELG5, ELG6 et ELG7.

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