Human endogenous foamy retrovirus and uses thereof

Details Human endogenous foamy retrovirus and uses thereof Human endogenous foamy retrovirus and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/867 (2006.01) C12N 7/01 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2501301

The invention relates to the discovery of an active human endogenous retrovirus (HERV), HERV-BZU, which appears to be the first instance of a true human foamy virus. HERV-BZU is infective, causes vacuolation in cultured human lymphocytes (under defined conditions), forms immature particles released to these vacuoles, and is closely related to HERV-K102/ K103 and other HERV-K Type I retroviruses. HERV-BZU seems to be transactivated by infection with bloodborne viruses. This suggests it may play a role in limiting viral invasion and replication and thus, may be a normal early host defense response to viremia. Plasma samples from healthy normal individuals do not contain HERV-BZU whereas individuals with virus- associated chronic diseases may have viral particles in their blood.

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