C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/64 (2006.01) A61K 38/48 (2006.01) A61K 48/00 (2006.01) C07K 16/40 (2006.01) C12N 15/57 (2006.01) C12Q 1/37 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2392076
This invention relates to newly identified, polypeptides and polynucleotides encoding such polypeptides, which hereinafter are referred to as IGS5, to their use in therapy and in identifying compounds which may be stimulators and/or inhibitors which are potentially useful in therapy, and to production of such polypeptides and polynucleotides. The polypeptides and polynucleotides are related to the metalloprotease family and preferably of human type. The invention also relates to inhibiting or stimulating/activating the action of such polypeptides and polynucleotides, to a vector containing said polynucleotides and to a host cell containing such vector. The invention further relates to a method for screening compounds capable to act as a stimulator or inhibitor of said IGS5 enzyme. The Polypeptides of the present invention are of interest in the context of several dysfunctions, disorders or diseases. The Polypeptides of the present invention are in particular of interest in the context of cardiovascular diseases.
L'invention concerne des polypeptides récemment identifiés, des polynucléotides codant pour ces polypeptides qui sont ici dénommés IGS5, leur application thérapeutique et leur utilisation pour l'identification de composés pouvant être des stimulateurs et/ou des inhibiteurs susceptibles d'avoir une utilité thérapeutique. L'invention concerne également l'obtention de ces polypeptides et de ces polynucléotides qui sont associés à la famille des métalloprotéases, de préférence du type humain. L'invention ambitionne d'inhiber ou stimuler/activer l'action de ces polypeptides et polynucléotides et concerne en outre un vecteur contenant ces polynucléotides et une cellule hôte renfermant ce vecteur. L'invention concerne finalement un procédé de criblage des composés capables de jouer le rôle de stimulateurs ou inhibiteurs de cette enzyme IGS5. Les polypeptides de cette invention trouvent une application dans le traitement de plusieurs dysfonctionnements, troubles ou maladies et plus particulièrement des maladies cardio-vasculaires.
Deleersnijder Willy
Weske Michael
Wiegers Rico
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Solvay Pharmaceuticals B.v.
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