Human eosinophil-derived basic protein

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2268016

The present invention provides a human eosinophil-derived basic protein (EBPH) and polynucleotides which identify and encode EBPH. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding EBPH and a method for producing EBPH. The invention also provides for use of EBPH and agonists, antibodies or antagonists specifically binding EBPH, in the prevention and treatment of diseases associated with expression of EBPH. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding EBPH for the treatment of diseases associated with the expression of EBPH. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding EBPH.

La présente invention concerne une protéine basique obtenue à partir d'éosinophiles humains (EBPH) et des polynucléotides identifiant et codant pour cette EBPH. Cette invention concerne également des vecteurs d'expression et des cellules hôtes, mis au point génétiquement, qui comprennent les séquences d'acides nucléiques codant pour l'EBPH, et un procédé permettant de produire l'EBPH. Cette invention prévoit également l'utilisation d'EBPH, d'agonistes, d'anticorps ou d'antagonistes se liant spécifiquement à l'EBPH, dans la prévention et le traitement de maladies associées à l'expression d'EBPH. De plus, cette invention prévoit l'utilisation de molécules antisens de polynucléotides codant pour l'EBPH dans le traitement de maladies associées à l'expression d'EBPH. Cette invention concerne également des techniques diagnostiques employant ce polynucléotide, des fragments ou le complément de celui-ci, et des anticorps se liant spécifiquement à l'EBPH.

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