Human fg01 gene and its applications

Details Human fg01 gene and its applications Human fg01 gene and its applications

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2761614

A human gene, fg01, on chromosome 8, is identified. This gene, and its expression product, human fg01, shares a homology under 70% with the corresponding murine gene, which has been linked to presentation of the Alzheimer's phenotype of Aß plaques and hyperphosphorylated tau tangles. Upregulation appears to suppress the Alzheimer's phenotype, which may be effective in preventing the onset of symptoms or progression of symptoms associated with AD. Screening methods are also set forth.

Cette invention concerne l'identification du gène humain fg01 présent sur le chromosome 8. Ce gène humain fg01 et son produit d'expression partagent une homologie inférieure à 70 % avec le gène murin correspondant, et s'avèrent liés à la présentation du phénotype des plaques Aß et des dégénérescences à tau hyperphosphorylées dans la maladie d'Alzheimer. La régulation à la hausse semble supprimer le phénotype de la maladie d'Alzheimer, et peut être efficace pour prévenir le début des symptômes ou la progression des symptômes associés avec la maladie d'Alzheimer. L'invention concerne également des méthodes de dépistage.

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