Human fgf-20 gene and gene expression products

Details Human fgf-20 gene and gene expression products Human fgf-20 gene and gene expression products

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/18 (2006.01) C07K 14/50 (2006.01) C07K 16/22 (2006.01) C12N 5/10 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2388637

This invention relates to human fibroblast growth factor (hFGF-20), and to variants thereof and to polynucleotides encoding FGF-20. The invention also relates to diagnostic and therapeutic agents related to the polynucleotides and proteins, including probes and antibodies, to methods of treating neuronal degenerative disease such as Parkinson's disease and to methods of treating disorders of the cochlea including those causing hearing loss. The invention also relates to rat fibroblast growth factor (rFGF-20), and to variants thereof and polynucleotides encoding rFGF-20.

La présente invention concerne un facteur de croissance des fibroblastes humain (hFGF-20), des variants de ce dernier et des polynucléotides codant le FGF-20. L'invention se rapporte également à des agents diagnostiques et thérapeutiques liés aux polynucléotides et protéines de l'invention, y compris des sondes et des anticorps, à des procédés de traitement d'une maladie neurodégénérative telle que la maladie de Parkinson et à des procédés de traitement des troubles cochléaires, y compris les troubles entraînant une perte d'audition. L'invention concerne aussi le facteur de croissance des fibroblastes du rat (rFGF-20), des variants de ce dernier et des polynucléotides codant le rFGF-20.

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