Human fgf23 protein mutants decreasing blood phosphorus level

Details Human fgf23 protein mutants decreasing blood phosphorus level Human fgf23 protein mutants decreasing blood phosphorus level

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 35/76 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01) A61P 3/12 (2006.01) C07K 14/50 (2006.01) C12N 5/10 (2006.01) C12N 15/10 (2006.01) C12P 21/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2433171

A full-length cDNA encoding human FGF23 protein is isolated and a mutant of this cDNA with a single amino acid substitution is constructed by a mutagenesis method. When expressed in vivo, this mutant exerts an effect of lowering blood phosphorus level. It is expected that this mutant and DNA encoding the same are applicable to remedies for hyper phosphatemia or gene therapy therefor.

On isole un ADNc pleine longueur codant pour la protéine FGF23 humaine et on construit un mutant dudit ADNc possédant une seule substitution d'acide aminé, par un procédé de mutagenèse. Lorsqu'il est exprimé <i> in vivo</i>, ledit mutant exerce un effet d'abaissement du taux de phosphore dans le sang. Ledit mutant et l'ADN le codant sont applicables à des remèdes pour la phosphatémie ou pour la thérapie génique prévue à cet effet.

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