C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/16 (2006.01) A61K 38/24 (2006.01) A61P 43/00 (2006.01) C07K 14/72 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) G01N 33/566 (2006.01) G01N 33/74 (2006.01)
Patent
CA 2106061
The present invention embraces essentially pure human FSH receptor, or a fragment or mutant thereof which binds FSH, DNA encoding said receptor, fragment or mutant, expression vectors comprising said DNA, cells transfected with said expres-sion vectors, and methods of producing said receptor, fragment or mutant by culturing said transfected cells. The present inven-tion also includes pharmaceutical compositions comprising said receptor, fragment or mutant, as well as methods of treating pa-tients with such compositions to reduce endogenous FSH bioactivity. An improved assay for human FSH using the receptor, fragment or mutant of the present invention is also disclosed.
Cheng Shirley V. Y.
Kelton Christie A.
Nugent Noreen P.
Schweickhardt Rene L.
Applied Research Systems Ars Holding N.v.
Gowling Lafleur Henderson Llp
Merck Serono Sa
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