Human follicle stimulating hormone receptor

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/16 (2006.01) A61K 38/24 (2006.01) A61P 43/00 (2006.01) C07K 14/72 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) G01N 33/566 (2006.01) G01N 33/74 (2006.01)

Patent

CA 2106061

The present invention embraces essentially pure human FSH receptor, or a fragment or mutant thereof which binds FSH, DNA encoding said receptor, fragment or mutant, expression vectors comprising said DNA, cells transfected with said expres-sion vectors, and methods of producing said receptor, fragment or mutant by culturing said transfected cells. The present inven-tion also includes pharmaceutical compositions comprising said receptor, fragment or mutant, as well as methods of treating pa-tients with such compositions to reduce endogenous FSH bioactivity. An improved assay for human FSH using the receptor, fragment or mutant of the present invention is also disclosed.

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