Human gamma interferon-specific receptor protein, antibody...

Details Human gamma interferon-specific receptor protein, antibody... Human gamma interferon-specific receptor protein, antibody...

C - Chemistry, Metallurgy

07

K

167/139, 167/103

C07K 14/715 (2006.01) A61K 39/395 (2006.01) C07K 16/28 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1323728

Abstract. Analysis of [125I]. interferon gamma cross-linked to its receptor on various human cells by SDS-PAGE revealed that there are at least three different types of human interferon gamma receptors. In WISH, HeLa, FS11 and other tissue cells an Mr 90,000-105,000 receptor was found. In monocytes and in the myeloid cell line KG-1 an Mr 140,000 receptor was found while in Daudi lymphoblastoid cells an Mr 95,000-115,000 receptor was found. The various receptors were isolated from these cells by extraction followed by affinity chromotography on an immobilized interferon gamma column. The resulting purified preparations retained their original affinity for interferon gamma and were used for immunizing mice and subsequent development of highly specific antibodies.

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