C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61P 15/00 (2006.01) A61P 15/18 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2425174
Disclosed herein are novel nucleic acid and protein sequences that are essential to fertility. In particular, human Mater cDNA and protein sequences are provided. Functional MATER is required for female fertility; zygotes that arise from Mater null oocytes do not progress beyond the two-cell stage. Methods are described for using Mater molecules in diagnoses, prognosis, and treatment of fertility and reduced fertility. Also provided are methods for using MATER as a contraceptive agent. The disclosure also describes compounds involved in such methods, and the identification of such compounds.
L'invention concerne un acide nucléique et des séquences protéiniques nouveaux qui sont essentiels pour la fertilité. En particulier, l'invention concerne des séquences d'ADNc Mater humain et protéiniques. Le MATER fonctionnel est nécessaire pour la fertilité féminine; les zygotes qui découlent d'oocytes zéro Mater ne dépassent pas le niveau de deux cellules. L'invention concerne des procédés d'utilisation de molécules Mater dans les diagnostics, pronostics et traitement d'infertilité et de fertilité diminuée. Elle concerne également des procédés d'utilisation de MATER en tant qu'agent de contraception. Elle concerne enfin des composés entrant dans ces procédés et leur identification.
Nelson Lawrence M.
Tong Zhi-Bin
Department Of Health & Human Services The Government Of The United States Of America As Represented By
Smart & Biggar
LandOfFree
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