C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) C07K 14/475 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2299586
The distal and proximal promoters for the human glial cell line-derived neurotrophic factor (GDNF) gene are provided. In addition, constructs comprising a human GDNF promoter and a reporter gene, a vector comprising the construct and a host cell comprising the vector are provided, as is a method for screening compounds capable of modulating the expression of GDNF by stimulating GDNF promoter-directed transcription.
L'invention concerne les promoteurs distaux et proximaux pour le gène du GDNF (glial celle line-derived neurotrophic factor). Elle concerne en outre des constructions comprenant un promoteur de GDNF humain et un gène marqueur, un vecteur comprenant cette construction et une cellule hôte comprenant le vecteur, ainsi qu'un procédé permettant de sélectionner des composés capables de moduler l'expression de GDNF en stimulant la transcription dirigée par le promoteur de GDNF.
Baecker Preston Albert
Johnson Randolph Mellus
Lee Walter Hom
Verity Adrian Neil
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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