Human glucagon-like 1 peptide receptor

Details Human glucagon-like 1 peptide receptor Human glucagon-like 1 peptide receptor

C - Chemistry, Metallurgy

12

N

C12N 15/16 (2006.01) C07K 14/605 (2006.01) C07K 14/72 (2006.01) C12N 5/10 (2006.01) G01N 33/567 (2006.01)

Patent

CA 2168448

The human GLP-1 receptor is cloned and used in an in vitro assay to screen for compounds that specifically bind to the human GLP-1 receptor, including compounds effective to reduce symptoms of diabetes. The invention includes the assay, the cloned human receptor used in the assay, an isolated human GLP-1 receptor free of other human proteins, and compounds identified through the use of this novel, cloned receptor, which selectively bind the human GLP-1 receptor.

Le récepteur humain de GLP-1 est cloné et utilisé dans un essai in vitro pour cribler les composés qui se lient spécifiquement au récepteur humain de GLP-1, y compris les composés efficaces pour réduire les symptômes du diabète. L'invention porte sur l'essai, sur le récepteur humain cloné utilisé pour l'essai, sur un récepteur humain isolé de GLP-1 ne contenant pas d'autres protéines humaines, et sur des composés identifiés grâce à l'utilisation de ce nouveau récepteur cloné qui se lie sélectivement au récepteur humain de GLP-1.

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