Human growth and differentiation factor gdf-5

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/495 (2006.01) A61K 38/18 (2006.01) A61K 38/48 (2006.01) C07K 14/475 (2006.01) C12N 15/18 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2657349

This invention relates to the production and use of pharmaceutical growth factor compositions with novel characteristics, e.g. improved solubility and controlled release characteristics under physiological conditions. Said compositions of one or more precursor proteins of growth factors of the GDF family provoke morphogenic effects such as for example growth, differentiation, protection and regeneration of a variety of tissues and organs, e.g. bone, cartilage, tendons, ligaments, nerves and skin. The invention can be advantageously used for the healing of tissue-destructive injuries and for the prevention or therapy of degenerative disorders.

La présente invention concerne la production et l'utilisation de compositions pharmaceutiques de facteur de croissance dotées de nouvelles caractéristiques, notamment une solubilité améliorée et des caractéristiques de libération régulée dans des conditions physiologiques. Lesdites compositions, constituées d'une ou de plusieurs protéines qui sont les précurseurs des facteurs de croissance de la famille des GDF, produisent des effets morphogéniques tels que par exemple la croissance, la différenciation, la protection et la régénération d'une variété de tissus et d'organes, notamment les os, les cartilages, les tendons, les ligaments, les nerfs et la peau. L'invention peut être avantageusement utilisée pour obtenir la cicatrisation de lésions destructrices de tissus et pour la prévention ou le traitement de troubles dégénératifs.

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