Human growth hormone

Details Human growth hormone Human growth hormone

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A61K 38/27 (2006.01) C07K 14/61 (2006.01) C07K 16/26 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2182205

There are provided DNA (or RNA) polynucleotide sequences encoding naturally occurring splice variants of human growth hormone, hGHV-2 (88) and hGHV-3 (53) as well as analogs and derivatives thereof, which both lack nucleotide sequences normally present in the gene which codes for wild-type human growth hormone. The growth hormone variants of the present invention are of human origin and are useful for diagnostic, preventative and therapeutic purposes with respect to certain human diseases. The present invention is also related to a method for producing the human growth hormone variants by recombinant DNA techniques. A method of generating an antibody directed against and therefore inhibiting the activity of wild-type growth hormone is also provided.

Séquences polynucléotidiques d'ADN (ou d'ARN) codant des variantes d'épissage naturelles d'hormone de croissance humaine hGHV-2 (88) et hGHV-3 (53) ainsi que leurs analogues et dérivés, qui sont toutes deux exemptes des séquences nucléotidiques normalement présentes dans le gène qui code pour l'hormone de croissance humaine de type sauvage. Les variantes d'hormone de croissance de la présente invention sont d'origine humaine et sont utiles à des fins diagnostiques, de prévention et thérapeutiques, pour certaines maladies humaines. La présente invention concerne également un procédé de production de variantes d'hormones de croissance humaine par des techniques de génie génétique. Un procédé de production d'un anticorps dirigé contre l'activité de l'hormone de croissance de type sauvage et, partant, inhibant ladite activité est en outre décrit.

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