Human growth hormone variants

Details Human growth hormone variants Human growth hormone variants

C - Chemistry, Metallurgy

07

K

C07K 14/61 (2006.01) A61K 38/27 (2006.01) A61K 47/48 (2006.01) A61P 5/06 (2006.01) A61P 35/00 (2006.01) C07K 17/08 (2006.01) C12N 15/18 (2006.01)

Patent

CA 2230492

Human growth hormone variants are disclosed having enhanced affinity for the growth hormone receptor. Also disclosed are human growth hormone variants conjugated to one or more chemical groups, such as poly(ethylene glycol), which is believed to prolong the in vivo half-life of the variants.

La présente invention concerne des variants de l'hormone de croissance humaine qui ont une affinité accrue pour le récepteur de l'hormone de croissance. L'invention concerne aussi des variants conjugués à un ou plusieurs groupes chimiques, comme le poly(éthylène glycol), dont on croit qu'il prolonge la demi-vie in vivo de ces variants.

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