Human hairless gene, protein and uses thereof

Details Human hairless gene, protein and uses thereof Human hairless gene, protein and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A01K 67/00 (2006.01) A61K 8/60 (2006.01) A61K 8/64 (2006.01) A61K 39/395 (2006.01) A61Q 7/00 (2006.01) A61Q 7/02 (2006.01) C07K 14/00 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2362320

The present invention provides an isolated nucleic acid which encodes a wildtype or mutant human hairless protein. The present invention further provides an isolated wildtype or mutant human hairless protein. In addition, the present invention provides methods of isolating a nucleic acid encoding a wildtype human hairless-related protein in a sample containing nucleic acid, methods for identifying a compound which is capable of enhancing or inhibiting expression of a human hairless protein, methods for identifying a binding coumpound which is capable of forming a complex with a human hairless protein, and methods for identifying an inhibitory compound which is capable of interfering the capacity of a human hairless protein to form a complex with the binding compound. The invention also provides a transgenic animal and pharmaceutical compositions and methods for treating a human hairless condition.

Cette invention concerne un acide nucléique isolé qui code une protéine de calvitie humaine du type sauvage ou mutant, ainsi qu'une protéine isolée de calvitie humaine du type sauvage ou mutant. Cette invention concerne également des procédés permettant d'isoler un acide nucléique codant une protéine liée à la calvitie humaine du type sauvage dans un échantillon contenant de l'acide nucléique, des procédés permettant d'identifier un composé qui est capable d'accroître ou d'inhiber l'expression d'une protéine de calvitie humaine, des procédés permettant d'identifier un composé de liaison qui est capable de former un complexe avec une protéine de calvitie humaine, et des procédés permettant d'identifier un composé inhibiteur qui est capable d'entraver la capacité d'une protéine de calvitie humaine de former un complexe avec le composé de liaison. Cette invention concerne également un animal transgénique, des compositions pharmaceutiques et des procédés de traitement de la calvitie chez l'homme.

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