C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/24 (2006.01) C07K 16/40 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2392703
The present invention relates to newly identified polynucleotides, and polypeptides encoded by such polynucleotides, the use of such polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, a polypeptide of the present invention is a heparanase-related endoglucuronidase. The invention also relates to vectors and host cells comprising a polynucleotide of the invention. Furthermore, the invention relates to antibodies directed to polypeptides according to the present invention and to pharmaceutical compositions and diagnostic reagents comprising such antibodies, polypeptides or polynucleotides. The invention further relates to a method of altering, modifying or otherwise modulating the level of expression of the heparanase-related endoglucuronidase in a cell or in a organism. A further aspect of the invention are assay systems suitable for identifying modulators, e.g. agonists or antagonists of such polypeptides.
L'invention concerne des polynucléotides nouvellement identifiés, ainsi que des polypeptides codés par ces polynucléotides, l'utilisation de tels polypeptides, de même que la production de ces polynucléotides et polypeptides. L'invention concerne notamment un polypeptide qui est une endoglucoronidase apparentée à l'héparanase, ainsi que des vecteurs et cellules hôtes comprenant un polynucléotide de l'invention. En outre, l'invention concerne des anticorps dirigés contre les polypeptides de l'invention, et des compositions pharmaceutiques et réactifs diagnostiques comprenant des tels anticorps, polypeptides ou polynucléotides. Enfin, l'invention concerne un procédé de modification, ou de modulation d'une autre manière, du niveau d'expression de l'endoglucuronidase apparentée à l'héparanase, dans une cellule ou dans un organisme, ainsi que des systèmes de dosage conçus pour identifier des modulateurs, par exemple des agonistes ou antagonistes de tels polypeptides.
Siemeister Gerhard
Weiss Bertram
Marks & Clerk
Schering Aktiengesellschaft
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