Human hepatic progenitor cells and methods of use thereof

Details Human hepatic progenitor cells and methods of use thereof Human hepatic progenitor cells and methods of use thereof

C - Chemistry, Metallurgy

12

N

C12N 5/071 (2010.01) A61K 35/407 (2006.01) A61P 1/16 (2006.01) C12Q 1/02 (2006.01) C12Q 1/70 (2006.01)

Patent

CA 2553303

Liver progenitor cells immunoreactive for CD117, as well as for CD34 capable of proliferating in a culture; and differentiating in vivo into a hepatocyte, a cholangiocyte or a sinusoidal cell are provided. The cultures can be expended over a large number of passages and integrate well after transplantation into adult liver.

L'invention concerne des cellules progénitrices immunoréactives du foie à CD117, ainsi qu'à CD34 capables de proliférer dans une culture et de se différentier in vivo en cellules hépatocytes, cholangiocytes ou sinusoïdales. Les cultures peuvent être étalées sur un nombre élevé de passages et bien s'intégrer après la transplantation dans un foie adulte.

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