Human hepatoma-derived growth factor-2

Details Human hepatoma-derived growth factor-2 Human hepatoma-derived growth factor-2

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A61K 31/70 (2006.01) A61K 38/18 (2006.01) A61K 48/00 (2006.01) C07K 14/475 (2006.01) C07K 14/50 (2006.01) C07K 16/22 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2223733

A human hepatoma-derived growth factor polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the stimulation of tissue repair and tissue growth. Antagonists against such polypeptides and their use as a therapeutic to retard tumor growth and scarring is also disclosed. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.

L'invention concerne un facteur de croissance dérivé de l'hépatome humain et l'ADN (ARN) codant ce polypeptide, ainsi qu'un procédé pour produire ledit polypeptide par des techniques de recombinaison. L'invention concerne également des procédés d'utilisation desdits polypeptides pour la stimulation de la réparation et la croissance des tissus. L'invention concerne également des antagonistes de ces polypeptides et leur utilisation thérapeutique pour retarder la croissance de tumeurs et favoriser la cicatrisation. L'invention concerne également des méthodes diagnostiques pour détecter les mutations dans la séquence de codage et les modifications de la concentration de polypeptides dans un échantillon prélevé sur un hôte.

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