Human high-affinity neurotranmitter uptake system

Details Human high-affinity neurotranmitter uptake system Human high-affinity neurotranmitter uptake system

C - Chemistry, Metallurgy

12

N

150/16, 195/1.36

C12N 5/10 (2006.01) C07K 14/47 (2006.01) C12Q 1/04 (2006.01) G01N 33/94 (2006.01)

Patent

CA 1339694

Non-primate or primate cells are provided comprising a functional human transporter for neurotransmitter uptake. The cells allow for dissection of the mechanism of neurotransmitter transport, as well as screening for agonists and antagonists of the neurotransmitter with respect to its uptake. Methods are provided for producing such cells. Specifically, the cells are transformed with human DNA comprising the gene encoding for the neurotransmitter transporter, whereby this protein(s) is expressed and transported to the membrane and is capable of functioning to transfer the neurotransmitter from the extracellular space intracellularly.

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