Human homologue of yeast helicase and uses thereof

Details Human homologue of yeast helicase and uses thereof Human homologue of yeast helicase and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/61 (2006.01) C12N 9/90 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2388149

The present invention provides a nucleic acid and amino acid sequence of a human Pif-1 type helicase. The invention also provides methods of screening for compounds that modulate the activity of human Pif-1 type helicase, as well as methods for affecting viability of a cell by contacting the cell with a human Pif-1 helicase modulator. Such contacting specifically increases or decreases the specific activity of the human helicase in the cell, and may affect its viability, by affecting telomere length regulatory processes.

La présente invention concerne un acide nucléique et une séquence d'acides aminés d'une hélicase humaine du type Pif-1. L'invention concerne également des méthodes de criblage de composés modulant l'activité de ladite hélicase humaine du type Pif-1, ainsi que des méthodes visant à influer sur la viabilité d'une cellule par la mise en contact de ladite cellule avec un modulateur de l'hélicase humaine du type Pif-1. Cette mise en contact, qui permet d'augmenter ou de réduire l'activité spécifique de l'hélicase humaine dans la cellule, peut influer sur la viabilité de cette dernière du fait de ses effets sur les procédés de régulation de la longueur des télomères.

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