Human igm antibody inducing apoptosis in hiv-infected cells...

Details Human igm antibody inducing apoptosis in hiv-infected cells... Human igm antibody inducing apoptosis in hiv-infected cells...

C - Chemistry, Metallurgy

07

K

C07K 16/18 (2006.01) A61K 39/395 (2006.01) A61P 31/18 (2006.01) C07K 16/28 (2006.01) C12N 5/16 (2006.01) C12N 15/13 (2006.01)

Patent

CA 2491859

A monoclonal antibody falling within the category of human IgM which specifically recognizes HIV-infected cells and induces apoptosis is obtained. Using the obtained antibody, it is intended to provide a remedy for patients suffering from HIV-infection, which contains as the active ingredient a human IgM antibody capable of specifically reacting with HIV-infected cells, inducing apoptosis in the infected cells and thus disrupting the cells, etc.

L'invention concerne la découverte d'un anticorps monoclonal de type IgM humain qui reconnaît spécifiquement les cellules infectées par le VIH et induit l'apoptose. A travers cet anticorps, on dispose d'un remède pour les patients infectés par le VIH. Le principe actif du remède considéré est un anticorps IgM humain capable de réagir spécifiquement avec les cellules infectées par le VIH, d'induire l'apoptose dans les cellules infectées, et donc d'entraîner la rupture cellulaire.

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