C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/12 (2006.01) C07K 16/28 (2006.01) C12N 5/20 (2006.01) C12P 21/08 (2006.01)
Patent
CA 2491861
A human IgM monoclonal antibody responding to HIV-infected cells too, which is characterized by lysing activated human lymphocytes, etc. under the mediation by a homologous human complement, is obtained. Using the thus obtained monoclonal antibody, it is intended to provide an immune reaction controlling remedy, etc. containing the human IgM monoclonal antibody which responds specifically to activated lymphocytes and induces cell lysis under the mediation by a homologous complement. Using the human IgM monoclonal antibody responding to activated human lymphocytes, it is also intended to provide an HIV remedy, etc. characterized by lysing and eliminating activated lymphocytes to thereby treat transplantation rejection and autoimmune diseases caused by an over-response of T lymphocytes as well as HIV infection
L'invention concerne la découverte d'un anticorps IgM monoclonal humain fournissant également une réponse aux cellules infectées par le VIH, qui assure la lyse de lymphocytes humains activés, entre autres, avec médiation par un complément homologue. Cet anticorps permet d'élaborer un remède de contrôle de réaction immunitaire, entre autres, renfermant ledit anticorps, qui fournit une réponse spécifique à des lymphocytes activés, avec médiation par un complément homologue. On peut aussi utiliser cet anticorps pour élaborer un remède anti-VIH, entre autres, assurant la lyse et l'élimination de lymphocytes activés, et permettant alors de traiter le rejet de greffe et les maladies auto-immunes résultant d'une réponse excessive des lymphocytes T ainsi que l'infection par le VIH.
Okada Hidechika
Okada Noriko
Okada Hidechika
Okada Noriko
Rogers Law Office
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