Human il-1 beta antagonists

Details Human il-1 beta antagonists Human il-1 beta antagonists

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61P 19/02 (2006.01) A61P 25/00 (2006.01) A61P 37/00 (2006.01) C07K 16/24 (2006.01)

Patent

CA 2509136

The present invention encompasses isolated antibodies, or antigen-binding portions thereof, that specifically bind mature human IL-1 Beta. These antibodies, or antigen-binding portions thereof, generally exhibit high binding affinities (low kooff values), reduced deamidation compared to the native antibody, and can be used to treat various diseases such as rheumatoid arthritis, osteoarthritis, or neuroinflammation.

La présente invention concerne des anticorps isolés, ou des parties de ces anticorps qui se lient à un antigène, se liant spécifiquement à l'IL-1.beta. humaine mature. Lesdits anticorps, ou lesdites parties de ces anticorps qui se lient à un antigène, présentent généralement de hautes affinités de liaison (faibles constantes cinétiques de dissociation k¿off?) et une désamidation réduite en comparaison de l'anticorps natif et ils peuvent être utilisés pour traiter diverses maladies telles que la polyarthrite rhumatoïde, l'ostéoarthrite ou la neuroinflammation.

Affiliated with

Also associated with

Rating

Human il-1 beta antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Human il-1 beta antagonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human il-1 beta antagonists will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1434304