Human il-3 variants

Details Human il-3 variants Human il-3 variants

C - Chemistry, Metallurgy

07

K

C07K 14/54 (2006.01) A61K 38/20 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2120707

2120707 9307171 PCTABS00021 Human IL-3 variants or mutants are characterised in that one or more amino acids in or adjacent to the fourth predicted .alpha.-helix of hIL-3 and/or one or more amino acids in the first predicted .alpha.-helix of hIL-3 is/are replaced by another amino acid. These variants or mutants are useful in the modulation of profileration, differentiation or functional activation of haemopoietic cells or non-haemopoietic cells expressing or made to express the IL-3 receptor.

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