C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/48 (2006.01) A61K 38/16 (2006.01) A61K 39/21 (2006.01) A61P 31/18 (2006.01) C07K 14/16 (2006.01) C12P 21/02 (2006.01)
Patent
CA 2459426
This invention provides stable HIV-1 pre-fusion envelope glycoprotein trimeric complexes. This invention also provides related polypeptides and compositions comprising pharmaceutically acceptable particles and the trimeric complexes operably affixed thereto. This invention further provides related nucleic acids, vectors, host cells, compositions, production methods, and prophylactic and therapeutic methods.
La présente invention concerne des complexes trimères stables de glycoprotéines de pré-fusion du VIH-1. L'invention concerne également des compositions et polypeptides correspondants comprenant des particules pharmaceutiquement acceptables auxquelles sont joints fonctionnellement les complexes trimères. L'invention concerne enfin des acides nucléiques correspondants, des vecteurs, des cellules hôtes, des compositions, des procédés de production, ainsi que des prophylaxies et des thérapies.
Binley James M.
Gardner Jason
Lu Min
Maddon Paul J.
Moore John P.
Cornell Research Foundation Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Progenics Pharmaceuticals Inc.
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