C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 31/70 (2006.01) C07H 21/00 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2211877
Disclosed are methods of inhibiting transcription using a synthetic oligonucleotide complementary to the Watson strand of a double-stranded DNA genome. Also disclosed are synthetic oligonucleotides which specifically inhibit transcription of the HIV-1 genome. Pharmaceutical compositions containing the synthetic oligonucleotides of the invention and methods of treating HIV infection using the oligonucleotides or pharmaceutical compositions of the invention are also provided.
On décrit des procédés pour inhiber la transcription, en utilisant un oligonucléotide de synthèse complémentaire du brin de Watson d'un génome d'ADN à deux brins. On décrit également des oligonucléotides de synthèse qui inhibent spécifiquement la transcription du génome du VIH-1, ainsi que des compositions pharmaceutiques contenant les oligonucléotides de synthèse de l'invention et des procédés de traitement d'infections causées par le VIH, utilisant ces oligonucléotides ou des compositions pharmaceutiques les contenant.
Agrawal Sudhir
Levina Asya
Metelev Valeri
Temsamani Jamal
Zamecnik Paul
Agrawal Sudhir
Hybridon Inc.
Levina Asya
Mbm & Co.
Metelev Valeri
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