C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2220670
A human inhibitor of apoptosis polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of degenerative diseases, rheumatoid arthritis, septic shock, as an antiviral defense mechanism and to prevent the death of cells during trauma and strokes. Antagonists against such polypeptides and their use as a therapeutic to promote cell development, kill viral infections, promote tissue differentiation and development and maintain tissue homeostasis are also disclosed (tumors). Diagnostic methods for detecting mutations in the nucleic acid sequence encoding hIAP-1 protein are also disclosed.
L'invention concerne un inhibiteur humain du polypeptide de l'apoptose et l'ADN (ARN) codant pour un tel polypeptide, ainsi qu'un procédé pour produire ce polypeptide, par des techniques de recombinaison. L'invention concerne, en outre, des procédés pour utiliser de tels polypeptides pour le traitement de maladies dégénératives, de la polyarthrite rhumatoïde, des chocs septiques, comme mécanisme de défense antiviral et pour empêcher la mort de cellules en cas de traumatisme ou d'attaque. L'invention concerne également des antagonistes de tels polypeptides et leur utilisation thérapeutique pour favoriser le développement cellulaire, empêcher les infections virales, favoriser la différentiation cellulaire, favoriser et maintenir l'homéostasie tissulaire (tumeurs). L'invention concerne enfin des méthodes de diagnostic pour détecter les mutations dans la séquence des acides nucléiques codant pour la protéine hIAP-1.
He Wei Wu
Hudson Peter L.
Rosen Craig A.
Gowling Lafleur Henderson Llp
Human Genome Sciences Inc.
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