C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/36 (2006.01) A61K 39/395 (2006.01) A61P 7/02 (2006.01)
Patent
CA 2616902
The present invention relates to new antibodies and fragments and derivatives thereof, which are particularly suited for the characterization of the structure and function of Factor VIII (FVIII) of the coagulation pathway, for the design of therapeutic strategies for eradication of FVIII inhibitors and for the use as a medicament. The invention also relates to cell lines producing the specific antibodies. The present invention furthermore relates to pharmaceutical compositions comprising the antibodies, fragments and/or derivatives of the invention and to methods of preventing and treating cardiovascular disorders by using the antibodies or fragments and derivatives thereof or pharmaceutical compositions thereof.
L'invention concerne de nouveaux anticorps, leurs fragments et dérivés, particulièrement adaptés pour caractériser la structure et la fonction du facteur VIII (FVIII) du trajet de coagulation, dans le but de concevoir des stratégies thérapeutiques servant à éradiquer des inhibiteurs de FVIII, ainsi qu'à l'utiliser sous forme de médicament. Elle concerne également des lignées cellulaires produisant ces anticorps spécifiques. Elle concerne, de plus, des compositions pharmaceutiques contenant ces anticorps, leurs fragments et/ou dérivés, et des méthodes permettant de prévenir et de traiter des troubles cardio-vasculaires au moyen de ces anticorps, de leurs fragments ou de leurs dérivés, ou de compositions pharmaceutiques à base de ces derniers.
Gilles Jean Guy
Jacquemin Marc
Saint-Remy Jean-Marie
Life Sciences Research Partners Vzw
Smart & Biggar
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