C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 38/20 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 14/54 (2006.01) C07K 14/545 (2006.01) C07K 14/715 (2006.01) C07K 16/24 (2006.01) C07K 16/42 (2006.01) C07K 17/08 (2006.01) C07K 19/00 (2006.01) C12N 15/25 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2255906
Nucleic acids encoding human IL-1.gamma., and purified IL-1.gamma. proteins and fragments thereof are provided. Polyclonal and monoclonal antibodies, both anti-IL-1.gamma. antibodies and anti-idiotypic antibodies which may be agonists or antagonists of human IL-1.gamma., are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are also provided, together with antagonists and receptors of human IL-1.gamma..
Cette invention concerne des acides nucléiques codant l'IL-1.gamma. d'origine humaine, ainsi que des protéine d'IL-1.gamma. purifiées et des fragments de ces dernières. Cette invention concerne également des anticorps polyclonaux et monoclonaux, tant des anticorps anti-IL-1.gamma. que des anticorps anti-idiotypiques, lesquels peuvent être des agonistes ou des antagonistes de l'IL-1.gamma. d'origine humaine. Cette invention concerne enfin des procédés d'utilisation de compositions à des fins diagnostiques et thérapeutiques, ainsi que des antagonistes et des récepteurs d'IL-1.gamma. d'origine humaine.
Bazan J. Fernando
Hardiman Gerard T.
Kastelein Robert A.
Sana Theodore R.
Timans Jacqueline C.
Schering Corporation
Swabey Ogilvy Renault
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