Human interleukin variants generated by alternative splicing

Details Human interleukin variants generated by alternative splicing Human interleukin variants generated by alternative splicing

C - Chemistry, Metallurgy

12

N

C12N 15/26 (2006.01) A61K 38/20 (2006.01) C07K 14/54 (2006.01) C07K 14/55 (2006.01) C07K 16/24 (2006.01) C12N 15/24 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2186854

Novel splice mutants of interleukins-2 and 4 are disclosed, which contain exons 1, 3 and 4 of the full-length mRNAs, but have exon 2 deleted. The proteins resulting from the expression of these splice mutants are useful in regulating the activity of the full-length interleukins.

La présente invention concerne de nouveaux mutants des interleukines 2 et 4 obtenus par épissage, ces mutants comportant les exons 1, 3 et 4 des ARNm pleine longueur, auxquels il manque cependant l'exon 2. Les protéines issues de l'expression de ces mutants obtenus par épissage sont utiles pour la régulation de l'activité des interleukines pleine longueur.

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