C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 39/00 (2006.01) C07K 1/36 (2006.01) C07K 14/47 (2006.01) C07K 14/575 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 5/20 (2006.01) C12P 21/08 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2050910
A substantially purified infra-acrosomal human sperm antigen useful in a contraceptive vaccine is disclosed herein. The antigen remains associated with human sperm after the acrosome reaction. In particular, it remains associated with the inner and outer acrosomal membranes. Modified antigens and fragments thereof prepared by protein modification techniques are also dis- closed as well as methods for purifying and using the antigens. Also disclosed are monoclonal and polyclonal antibodies to the antigen and methods of making and using such antibodies. Methods of use include purification of the antigen or use in various diagnostic techniques. Also disclosed are cDNA, expression vectors, and transformed microorganisms that produce the antigen.
Herr John C.
Wright Richard M.
Ridout & Maybee Llp
University Of Virginia Alumni Patents Foundation (the)
LandOfFree
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