Human kunitz-type protease inhibitor variants

Details Human kunitz-type protease inhibitor variants Human kunitz-type protease inhibitor variants

C - Chemistry, Metallurgy

12

N

C12N 15/15 (2006.01) A61K 38/57 (2006.01) C07K 14/81 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2127248

2127248 9314119 PCTABS00024 A variant of the C-terminal Kunitz-type protease inhibitor domain of the .alpha.3 chain of human type VI collagen, the variant comprising the amino acid sequence (I) wherein X1 represents H or 1-5 naturally occurring amino acid residues except Cys, X2-X14 each independently represents a naturally occurring amino acid residue, and X15 represents OH or 1-5 naturally occurring amino acid residues except Cys, with the proviso that at least one of the amino acid residues X1-X15 is different from the corresponding amino acid residue of the native sequence.

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