C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/02 (2006.01) A61K 31/00 (2006.01) A61K 31/045 (2006.01) A61K 31/05 (2006.01) A61K 31/155 (2006.01) A61K 31/195 (2006.01) A61K 31/20 (2006.01) A61K 31/35 (2006.01) A61K 31/352 (2006.01) A61K 31/44 (2006.01) A61K 31/4439 (2006.01) A61K 31/575 (2006.01) A61K 31/70 (2006.01) A61K 38/08 (2006.01) A61K 38/18 (2006.01) A61K 38/19 (2006.01) A61K 38/20 (2006.01) C12Q 1/26 (2006.01) C12Q 1/68 (2006.01) G01N 33/573 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2220156
Evidence for the presence of a human leukocyte type of 12-LO enzyme and its role in the pathogenesis of several major disease states or processes, including atherosclerosis, breast cancer, autoimmune and inflammatory disease, diabetic vascular and kidney disease and insulin resistance is described. Mediation, including the blockage of the human leukocyte 12-LO expression or enzyme activation, provides novel treatment to prevent or ameliorate these disease states.
Selon la présente invention, l'on a obtenu des indications de la présence d'une 12-lipoxygénase (12-LO) du type leucocytaire humain et du rôle qu'elle joue dans la pathogenèse de plusieurs états ou processus pathologiques importants, dont l'athérosclérose, le cancer du sein, les maladies inflammatoires et auto-immunes, les affections rénales et vasculaires diabétiques et l'insulinorésistance. La médiation, ainsi que l'inhibition, de l'activation enzymatique ou de l'expression de la 12-LO leucocytaire constitue un nouveau traitement permettant de prévenir ou de soigner ces états pathologiques.
Nadler Jerry L.
Natarajan Rama
City Of Hope
Sim & Mcburney
LandOfFree
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