Human lymphoid tissue in an immunocompromised host

Details Human lymphoid tissue in an immunocompromised host Human lymphoid tissue in an immunocompromised host

A - Human Necessities

61

K

A61K 35/26 (2006.01) A01K 67/00 (2006.01) A01K 67/027 (2006.01) C07K 16/00 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2063408

2063408 9116910 PCTABS00008 Human lymphoid tissue is introduced into an immunocompromised host to provide opportunities to investigate the effect of stimuli on the human immune system and obtain information and products for the stimulus. Particularly, methodology is provided for the production of human monoclonal antibodies by introducing lymphoid tissue into an immunocompromised host, stimulating the B-lymphocytes with an appropriate immunogen, harvesting the tissue and immortalizing and/or cloning the B-lymphocytes under conditions to obtain a stable supply of monoclonal antibodies.

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