Human macrophage inflammatory protein 2.beta.

Details Human macrophage inflammatory protein 2.beta. Human macrophage inflammatory protein 2.beta.

C - Chemistry, Metallurgy

12

N

C12N 15/19 (2006.01) A61K 38/19 (2006.01) C07H 21/04 (2006.01) C07K 14/52 (2006.01) C07K 16/24 (2006.01) C12N 5/16 (2006.01) C12P 21/08 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2086088

2086088 9200326 PCTABS00010 An attempt to identify the human counterpart of murine macrophage inflammatory protein 2 unexpectedly resulted in not one but two candidate sequences, designated hu-MIP-2.alpha. and hu-MIP-.beta., respectively. By using the DNA sequences and recombinant systems provided by this invention, one can obtain hu-MIP-2.beta., one of the two human counterparts to mMIP-2, substantially free of other human protein. This invention also provides antibodies reactive with hu-MIP-2$(b) polypeptides as well as immunoassay methods for determining hu-MIP-2.beta. and nucleotide probes for detecting nucleotide sequences encoding hu-MIP-2.beta. in biological samples.

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