Human mast cell-expressed membrane proteins

Details Human mast cell-expressed membrane proteins Human mast cell-expressed membrane proteins

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 39/00 (2006.01) C07H 21/04 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 15/00 (2006.01) C12P 15/00 (2006.01) C12P 21/06 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2472111

Mast cell-expressed membrane proteins that are highly expressed in human mast cells and the lungs as compared to brain, heart, kidney, liver, tracheal, and similar tissues. The proteins are transmembrane proteins involved in the regulation of mast cell and lung tissue function, including degranulation of mast cells. The preferred protein is a 187 amino acid transmembrane protein having an intercellular domain comprising amino acids 1 through 82, a transmembrane domain comprising amino acids 83 through 105, and an extracellular domain comprising amino acids 106 through 187 (SEQ ID NO:2).

L'invention concerne des protéines membranaires de mastocytes dont l'expression est très importante dans des mastocytes humains et dans le tissu pulmonaire en comparaison du tissu cérébral, rénal, cardiaque, hépatique, trachéal et des tissus semblables. Ces protéines sont des protéines transmembranaires impliquées dans la régulation de la fonction cellulaire des mastocytes et du tissu pulmonaire, incluant la dégranulation des mastocytes. La protéine préférée est une protéine transmembranaire de 187 acides aminés comportant un domaine intercellulaire constitué des acides aminés 1 à 82, un domaine transmembranaire constitué des acides aminés 83 à 105, et un domaine extracellulaire constitué des acides aminés 106 à 187 (SEQ ID NO:2).

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