Human metabotropic glutamate receptor subtype mglur6

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 39/395 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2215730

In accordance with the present invention, there are provided nucleic acids encoding human metabotropic glutamate receptor subtype mGluR6, and the proteins encoded thereby. In addition to being useful for the production of metabotropic glutamate receptor subtype mGluR6, nucleic acids of the invention are also useful as probes, thus enabling those skilled in the art, without undue experimentation, to identify and isolate related human receptor subunits. In addition to disclosing a novel metabotropic glutamate receptor subtype, mGluR6, the present invention also comprises methods for using the invention receptor subtype to identify and characterize compounds which affect the function of such receptor subtype, e.g., agonists, antagonists, and modulators of glutamate receptor function.

L'invention concerne des acides nucléiques codant le sous-type mGluR6 de récepteur métabotrope de glutamate chez l'homme, ainsi que les protéines codées par ledit sous-type. En plus de leur utilité pour la production du sous-type mGluR6 de récepteur métabotrope de glutamate, ces acides nucléiques peuvent également servir de sondes, ce qui permet d'identifier et d'isoler, sans procéder à une expérimentation non indispensable, des sous-ensembles apparentés de récepteurs de l'homme. En plus de ce nouveau sous-type de récepteur, mGluR6, l'invention concerne également des procédés d'utilisation dudit sous-type de récepteur afin d'identifier et de désigner des composés exerçant un rôle sur la fonction dudit sous-type, par exemple, des agonistes, des antagonistes et des modulateurs de la fonction du récepteur de glutamate.

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