C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/54 (2006.01) A01K 67/027 (2006.01) A61K 31/195 (2006.01) A61K 31/205 (2006.01) A61K 31/70 (2006.01) A61K 38/03 (2006.01) A61K 38/45 (2006.01) C07K 16/40 (2006.01) C12N 9/10 (2006.01) C12Q 1/48 (2006.01) C12Q 1/68 (2006.01) G01N 33/573 (2006.01) A61K 31/68 (1995.01)
Patent
CA 2217153
The invention features a method for detecting an increased likelihood of hyperhomocysteinemia and, in turn, an increased or decreased likelihood of neural tube defects or cardiovascular disease. The invention also features therapeutic methods for reducing the risk of neural tube defects, colon cancers and related cancers. Also provided are the sequences of the human methionine synthase gene and protein and compounds and kits for performing the methods of the invention.
L'invention décrit une méthode de détection du risque accru d'hyperhomocystéinémie ainsi que du risque réduit ou accru de malformations du tube neural ou de maladies cardiovasculaires. L'invention décrit également des méthodes thérapeutique visant à réduire le risque de malformations du tube neural, de cancer du côlon et de cancers connexes. On décrit aussi les séquences de la protéine et du gène de la méthionine synthétase humaine ainsi que des composés et des trousses pour appliquer les méthodes décrites dans l'invention.
Campeau Eric
Goyette Philippe
Gravel Roy A.
Leclerc Daniel
Rozen Rima
Martinex R&d Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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