Human methionine synthase reductase: cloning, and methods...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/53 (2006.01) A01K 67/027 (2006.01) C07K 16/40 (2006.01) C12N 9/02 (2006.01) C12N 9/10 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2360555

The invention features a novel gene encoding methionine synthase reductase. The invention also features a method for detecting an increased likelihood of hyperhomocysteinemia and, in turn, an increased or decreased likelihood of neural tube defects, cardiovascular disease, Down's Syndrome or cancer. The invention also features therapeutic methods for treating and/or reducing the risk of cardiovascular disease, Down's Syndrome, cancer, or neural tube defects. Also provided are the sequences of the human methionine synthase reductase gene and protein and compounds and kits for performing the methods of the invention.

La présente invention concerne un gène codant la synthétase réductase de la méthionine. L'invention concerne également un procédé permettant de détecter un risque accru d'hyperhomocystéinémie et, par conséquent, un risque accru ou atténué de défauts du tube neural, de pathologie cardio-vasculaire, de syndrome de Down ou de cancer. L'invention concerne en outre une thérapie permettant de traiter et/ou de réduire les risques de pathologie cardio-vasculaire, de syndrome de Down, de cancer ou de défauts du tube neural. L'invention concerne enfin le séquençage du gène de la synthétase réductase de méthionine humaine, ainsi que des protéines, des composés et des nécessaires permettant la mise en pratique des procédés de l'invention.

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