C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 31/7088 (2006.01) A61K 35/76 (2006.01) A61K 38/46 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07K 16/28 (2006.01) C07K 16/32 (2006.01) C07K 16/46 (2006.01) C07K 19/00 (2006.01) C12N 1/21 (2006.01) C12N 7/00 (2006.01) C12N 7/01 (2006.01) C12N 9/22 (2006.01) C12N 15/62 (2006.01) C12N 15/63 (2006.01) C12N 15/70 (2006.01) C12P 21/02 (2006.01) C12P 21/08 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01)
Patent
CA 2453435
The invention refers to a fully human miniantibody (scFv), called Erbicin, specific for the receptor ErbB2, with a phannacological, in particular antitumour, activity. It has been obtained from a larger fagmidic library (Griffin 1.) (19) of human synthetic scFv by panning (affinity selection on antigen) carried out on live cells that express various levels of ErbB2. The invention relates also to the DNA and amino acid sequences of said antibody, to the procedure for isolating it, to its use in therapy.
La présente invention concerne un mini-anticorps complètement humain (scFv), appelé erbicine, spécifique au récepteur ErbB2, qui possède une activité pharmacologique, en particulier antitumorale. Il a été obtenu à partir d'une bibliothèque plus large phagémide (Griffin 1.) (19) de scFv synthétique humaine par une méthode d'adhérence sur plastique (sélection d'affinité sur un antigène) effectuée sur des cellules vivantes qui expriment différents niveaux de ErbB2. La présente invention concerne également les séquences d'ADN et d'acides aminés dudit anticorps, la procédure permettant de l'isoler et son utilisation en thérapie.
D'alessio Giuseppe
de Lorenzo Claudia
Palmer Donald Balfour
Piccoli Renata
Ritter Mary Alice
Biotecnol S.a.
Sim & Mcburney
Universita' Degli Studi Di Napoli "federico Ii"
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