C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 9/127 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) C12P 21/08 (2006.01)
Patent
CA 2436779
The invention of the present application provides an isolated and purified human mitochondrial protein comprising the amino acid sequence of SEQ ID NO: 2 or SEQ ID NO: 4, which is a novel human protein promoting aggregation and fusion of mitochondria. The present invention also provides a polynucleotide encoding such a mitochondrial protein, antibody against such a mitochondrial protein, and a proteoliposome composed of such a mitochondrial protein and lipid. Mitochondrial proteins are useful for clarifying causes of mitochondrial diseases as well as for developing preventive and therapeutic methods thereof. Furthermore, antibodies and probes derived from genes encoding such proteins are potentially useful materials for diagnosis of condition of mitochondria in particular diseases. Furthermore, proteoliposomes provide measures for specific transfer of foreign genes or drugs targeted toward mitochondria.
L'invention concerne des protéines mitochondriales humaines, isolées et purifiées, contenant les séquences d'acide aminé représentées par SEQ ID NOS :2 et 4, ces nouvelles protéines humaines stimulant l'agrégation et la fusion de mitochondries. L'invention concerne aussi des polynucléotides codant ces protéines mitochondriales, des anticorps contre ces protéines mitochondriales et des protéoliposomes composés desdites protéines mitochondriales et de lipides. Ces protéines mitochondriales s'avèrent utiles pour comprendre les causes de maladies mitochondriales et pour développer des méthodes de prévention et de traitement de ces maladies. Les anticorps et les sondes provenant des gènes codant ces protéines sont des matériaux efficaces pour faire l'estimation de l'état mitochondrial dans le cadre de ces maladies. En outre, les protéoliposomes constituent un moyen de transfert spécifique d'un gène étranger ou d'une mitochondrie de ciblage médicamenteux.
Endo Hitoshi
Japan Science And Technology Corporation
Norton Rose Or S.e.n.c.r.l.,s.r.l./llp
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