Human monoclonal anti-peptide antibody and dna encoding thereof

Details Human monoclonal anti-peptide antibody and dna encoding thereof Human monoclonal anti-peptide antibody and dna encoding thereof

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) C07K 16/42 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2107761

Abstract Human monoclonal antibody directed against the peptide listed below was developed. The peptide exists in the CH4 region of human IgE and is related to signal transduction of chemical mediator release from sensitized mast cells and basophils. H-Lys-Thr-Lys-Gly-Ser-Gly-Phe-Phe-Val-Phe-NH2 The monoclonal antibody inhibits the histamine release from mast cells by stimulation with allergen. As the antibody thereof recognizes a specific amino acid sequence relates to allergic reactions, this antibody is useful as medicines and reagents.

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