Human monoclonal antibodies against cd20

Details Human monoclonal antibodies against cd20 Human monoclonal antibodies against cd20

C - Chemistry, Metallurgy

12

N

C12N 15/79 (2006.01) A01H 5/00 (2006.01) A01K 67/027 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C07K 16/42 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 5/22 (2006.01) C12N 5/24 (2006.01) C12N 15/63 (2006.01) C12Q 1/02 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2502552

Isolated human monoclonal antibodies which bind to and inhibit human CD20, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.

L'invention concerne des anticorps monoclonaux humains isolés qui se lient à l'antigène CD20 humain et l'inhibent, ainsi que des compositions et des molécules apparentées à base de ces anticorps. Les anticorps humains selon l'invention peuvent être produits par un transfectome ou dans un animal transgénique non humain, par exemple une souris transgénique, capable de produire plusieurs isotypes d'anticorps monoclonaux humains en subissant une recombinaison V-D-J et une commutation isotypique. L'invention concerne également des compositions pharmaceutiques comprenant ces anticorps humains, des animaux transgéniques non humains et des hybridomes qui produisent ces anticorps humains, ainsi que des procédés thérapeutiques et diagnostiques pour l'utilisation de ces anticorps humains.

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