Human monoclonal antibodies against cd25

Details Human monoclonal antibodies against cd25 Human monoclonal antibodies against cd25

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A01H 5/00 (2006.01) A01K 67/027 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 16/28 (2006.01) C07K 16/42 (2006.01) C12N 5/20 (2006.01) C12P 21/08 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2505991

Isolated human monoclonal antibodies which bind to and inhibit human CD25, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a hybridoma, a transfectoma or in a nonhuman transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, nonhuman transgenic animals, hybridomas and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.

L'invention concerne des anticorps monoclonaux humains isolés qui se lient à CD25 humain et inhibent ce dernier, ainsi que des compositions et des molécules associées à base d'anticorps. Les anticorps humains peuvent être produits au moyen d'un hybridome, un transfectome ou dans un animal transgénique non humain, par exemple une souris transgénique, capable de produire plusieurs isotypes d'anticorps monoclonaux humains par recombinaison V-D-J et par commutation isotypique. L'invention concerne aussi des compositions pharmaceutiques comprenant les anticorps humains, des animaux transgéniques non humains, des hybridomes et des transfectomes qui produisent les anticorps humains, ainsi que des procédés thérapeutiques et diagnostiques permettant d'utiliser les anticorps humains.

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